2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. 250/ Ton Get Latest Price. The overall health of the world economy will continue to play a major role in future demand for bisphenol A, as its derivatives' major end-use markets include automotive, construction, and electrical/electronic applications. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. These studies also addressed questions about how long it takes for the body to dispose of BPA. Poly(Bisphenol A-co-epichlorohydrin) glycidyl end-capped 25036-25-3: POLY(BISPHENOL A CARBONATE) 111211-39-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 42617-82-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 37225-26-6: Soya fatty acids, bisphenol A, epichlorohydrin polymer 66070-76-6: Bisphenol-A-polycarbonate 25037 . [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. 2005 2022 American Chemistry Council, Inc. Our line of powerful Liquid Epoxy Resins -including Bisphenol A, Modified Bisphenol A, Bisphenol A/F, Modified Bisphenol A/F, Bisphenol F offers the reliability, protection and performance you need, backed by the local customer support Only Olin can provide, virtually anywhere in the world. It belongs to the phenol class of aromatic organic compounds. Federal government websites often end in .gov or .mil. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. [34] These are not always removed and are known impurities in commercial samples of BPA. Durable and decorative floorings, such as terrazzo flooring, chip flooring and colored aggregate flooring, are made from epoxy resins. This compound is synthesized by the condensation of acetone with phenol. Developed physiologically based pharmacokinetic models that can be used to predict the level of internal exposure to the active and inactive forms of BPA. Government regulators have the responsibility of reviewing all studies and considering issues like study design and quality and whether the result of any particular study was repeated in other studies. Polycarbonate plastic is used to make critical components of many medical devices and their housings. Bisphenol A was first synthesized by A.P. Pathways include photo-oxidation, or reactions with minerals such as goethite which may be present in soils and sediments. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Bisphenol A was investigated in the 1930's during the search for synthetic estrogens. FDAs current perspective, based on its most recent safety assessment, is that BPA is safe at the current levels occurring in foods. Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. Liquid Epoxy Resins Show entries The primary source of exposure to BPA for most people is through the diet. Dianin in 1891. [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [106][107] BPA appears able to effect development and reproduction in a wide range of wildlife,[107] with certain species being particularly sensitive, such as invertebrates and amphibians.[106]. Because of the way BPA is processed in the body, it is very unlikely that exposure to BPA at typical levels could cause health effects. FDA will continue to participate in discussions with our international regulatory and public health counterparts who are also engaged in assessing the safety of BPA. Copyright 2022 ChemicalBook. The chemical formula is (CH 3 ) 2 C(C 6 H 4 OH) 2. It is also known to exhibit strong endocrine-disrupting ability. The method is a modification of NIOSH P&CAM Chemical Name: Hydrogenated Bisphenol A Epoxy Resin CAS No. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. The lowest molecular weight an epoxy resin of the DGEBA type can have is 340, but if two elements together can form different molecular weights when they react, the epoxy resin will contain a mixture of epoxy molecules of varying lengths. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. 2010 Sep 1;247(2):158-65. d) Doerge DR, Twaddle NC, Vanlandingham M, Brown RP, Fisher JW. [2]FDA Science Board Subcommittee on Bisphenol A. The .gov means its official.Federal government websites often end in .gov or .mil. Furthermore, composite . Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. [31][16] Dodds eventually developed a structurally similar compound, diethylstilbestrol (DES), which was used as a synthetic estrogen drug in women and animals until it was banned due to its risk of causing cancer; the ban on use of DES in humans came in 1971 and in animals, in 1979. What is the formula of phenol formaldehyde resin? The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. These meetings are listed in the NIEHS Events Calendar and are open to the general public. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. The ACC petition demonstrated, from publicly available information and information collected from industry sources, that the use of polycarbonate resins in baby bottles and sippy cups had been abandoned. Bisphenol A (BPA) is a chemical used to make polycarbonate plastic. Other Details: - Bisphenol resin is extensively used with consumer products such as applying coatings inside of food and beverage cans as this leave no bad effects or any risk of hazard to human health. The review was documented in four memoranda and their attachments: Strong consumer and scientific interest in the safety of BPA has prompted FDA to support additional studies to provide further information and address apparent inconsistencies in the scientific literature about BPA. [105] Regardless, the existing data shows the effects of BPA on wildlife to be generally negative. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. [70][71] The body first converts it into more water-soluble compounds via glucuronidation or sulfation, which are then removed from the body through the urine. [98], In all cases, wastewater treatment can be highly effective at removing BPA, giving reductions of 9198%. The performance represented by each part of the Bisphenol A-type epoxy resin is shown here: Araldite? [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. The reaction process is as follows: Epoxy is the family of basic components or cured end products of epoxy resins.Epoxy resins, also known as polyepoxides, are a class of reactive prepolymers and polymers which contain epoxide groups. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Extensive scientific dataabout BPA provides consumers with information about BPA safety and help put public confusion about BPA into perspective: If I buy a BPA-free product, is it safer? The manufacturing of epoxy resins and vinyl ester resins account for 25-30% of BPA use. Toxicol Sci. By 2009, FDA released reassessments of studies cited in the NTP Monograph in addition to other relevant studies that became available after the Monographs release. The FDAs National Center for Toxicological Research is continuing with an additional study: Rodent chronic toxicity study, which is currently underway. It is classified as a bisphenol, and a close molecular analog of Bisphenol A (BPA). [36] It may be purified by recrystallisation from acetic acid with water. Epoxy vinyl ester resins (VER), Often shortened to vinyl esters, are an important class of high-performance thermoset molding resins. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. Health care providers depend on medical devices and equipment made with BPA for a transparent view within the human body so they can check for the presence of air bubbles or other obstructions during medical procedures. Based on the effects of metabolism, internal exposures to the active form of BPA following oral administration are predicted to be below 1% or less of the total BPA level administered. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). [33] An excess of phenol is used to ensure full condensation and to limit the formation of byproducts, such as Dianin's compound. [22][17][72], The health effects of BPA have been the subject of prolonged public and scientific debate,[12][13][14] with PubMed listing more than 16,000 scientific papers as of 2022. Dont microwave polycarbonate plastic food containers. Usage/Application: Polycarbonate , Epoxy resin, Thermal paper. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. Use the browser controls to adjust the font size, or print this page. An official website of the United States government. As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. Many BPA-containing materials are non-obvious but commonly encountered,[17] and include coatings for the inside of food cans,[18] clothing designs,[19] shop receipts,[20] and dental fillings. MAIN APPLICATIONS Bisphenol A Epoxy is widely used in the manufacture of: Epoxy resins; Phenolic resins . In particular, infants are considered to be at greater risk,[83] leading to bans on the use of BPA in baby bottles and related products by the US,[84] Canada,[85] and EU[86] amongst others. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. Toxicol Lett. The epoxide resins (also widely known as epoxy resins and, occasionally, as ethoxyline resins) are characterised by the possession of more than one 1,2-epoxy group (I) per molecule. Lactational transfer of bisphenol A in Sprague-Dawley rats. Order: 18 Tons Shandong Near Chemical Co., Ltd. View larger video & image Contact Now Hot Sale Bisphenol a CAS No. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. 1675-54-3 Chemical Name: BISPHENOL A DIGLYCIDYL ETHER RESIN CBNumber: CB3749115 Molecular Formula: C21H24O4 Molecular Weight: 340.41 MDL Number: MFCD00080480 MOL File: 1675-54-3.mol MSDS File: SDS Modify Date: 2022-12-30 16:20:48 Request For Quotation BISPHENOL A DIGLYCIDYL ETHER RESIN Properties SAFETY Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. In the United States, FDA is the agency charged with this review for food contact applications. 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. In addition to receptor binding, the compound has been found to affect Leydig cell steroidogenesis, including affecting 17-hydroxylase/17,20 lyase and aromatase expression and interfering with LH receptor-ligand binding. In recent years, many claims have been made about the health effects of BPA. Epoxy resin | C21H25ClO5 | CID 169944 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Sign in to download full-size image Plastic containers have recycle codes on the bottom. Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2.It has two phenol functional groups on either side of a sulfonyl group. Chemical Economics Handbook. Bisphenol-A, commonly abbreviated as BPA, is an organic compound with the chemical formula (CH 3) 2 C (C 6 H 4 OH) 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. Its current uses are as a primary monomer in polycarbonate plastic and epoxy resins. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. One reason people may be concerned about BPA is because human exposure to BPA is widespread. Reprod Toxicol. Is there concern that exposure to BPA can cause harm or result in serious diseases? To address these questions the National Toxicology Program, partnering with FDAs National Center for Toxicological Research is carrying out in-depth studies to answer key questions and clarify uncertainties about BPA. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers. J Appl Polym Sci . [9][10] For epoxy resin, it is first converted to its diglycidyl ether (usually abbreviated BADGE or DGEBA). Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. General description. Diglycidyl ether of bisphenol A epoxy resin (EPOLAM 2017), and 3-minomethyl-3,5,5 trimethylclohexylamine hardener (EPOLAM 2018). [38][39][40] Spectroscopic data is available from AIST.[41]. 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